Protein Name interleukin 13
Organism Homo sapiens
Gene ID 3596
Gene Symbol

IL13

UniProt P35225 (IL13_HUMAN)
Relationships Total Number of functionally related compound(s) : 698
Total Number of Articles : 964
Description

interleukin 13

Gene Summary

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

synonyms
  • interleukin-13
  • IL-13
  • P600
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Properties