Title : Effect of various metals on intercellular adhesion molecule-1 expression and tumour necrosis factor alpha production by normal human keratinocytes.

Pub. Date : 1994

PMID : 7864660






3 Functional Relationships(s)
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1 Our aim was to assess the effects of sensitizing metal haptens (nickel, cobalt and chromium) compared with the toxic metal cadmium on the induction of ICAM-1 and the production of TNF alpha by epidermal cells. Nickel intercellular adhesion molecule 1 Homo sapiens
2 Using FACS analysis, ICAM-1 expression was found to be induced only by nickel. Nickel intercellular adhesion molecule 1 Homo sapiens
3 These results indicate that the metals studied are able to induce an aggressive cellular effect, and that nickel, by its ICAM-1 induction, may play a major role in the keratinocyte activation state during allergic contact dermatitis. Nickel intercellular adhesion molecule 1 Homo sapiens