Title : Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase and citrate synthase by sulfoxides and sulfones of substrate-analogue CoA-thioether derivatives.

Pub. Date : 1995 Jan 15

PMID : 7851398






3 Functional Relationships(s)
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1 Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase and citrate synthase by sulfoxides and sulfones of substrate-analogue CoA-thioether derivatives. Sulfones citrate synthase Homo sapiens
2 Sulfoxides and sulfones of substrate analogues of citrate synthase were also prepared. Sulfones citrate synthase Homo sapiens
3 When tested in the appropriate reaction with citrate synthase, the sulfoxide and sulfone derivatives were competitive inhibitors, but their Ki values were greater than the Km values of the corresponding unmodified substrates. Sulfones citrate synthase Homo sapiens