Pub. Date : 1994 Oct
PMID : 7851279
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of repeated amphetamine administration on the proopiomelanocortin mRNA level in the rat pituitary: an in situ hybridization study. | Amphetamine | proopiomelanocortin | Rattus norvegicus |
| 2 | The effect of single and repeated administration of amphetamine (5 mg/kg i.p., twice daily, 14 days) on the proopiomelanocortin (POMC) mRNA level was investigated in the rat pituitary. | Amphetamine | proopiomelanocortin | Rattus norvegicus |
| 3 | The effect of single and repeated administration of amphetamine (5 mg/kg i.p., twice daily, 14 days) on the proopiomelanocortin (POMC) mRNA level was investigated in the rat pituitary. | Amphetamine | proopiomelanocortin | Rattus norvegicus |
| 4 | In situ hybridization histochemistry, using a 35S-d-ATP-labelled deoxyoligonucleotide probe and densitometric analysis of autoradiograms, showed that repeated administration of amphetamine moderately increased the POMC mRNA level (by approximately 16%) in the anterior and the intermediate lobes of the pituitary at 72, but not 2, hr after the last injection. | Amphetamine | proopiomelanocortin | Rattus norvegicus |
| 5 | Adrenalectomy (48 h after the last drug injection) increased the POMC mRNA level only in the anterior lobe of repeated saline- and amphetamine-treated rats by 59 and 67%, respectively. | Amphetamine | proopiomelanocortin | Rattus norvegicus |
| 6 | These results suggest that repeated amphetamine administration leads to a delayed and moderate increase in POMC biosynthesis in the rat pituitary. | Amphetamine | proopiomelanocortin | Rattus norvegicus |