Title : Effects of cytostatic agents on the expression of epidermal growth factor receptor in ovarian cancer cells.

Pub. Date : 1994 Sep-Oct

PMID : 7847819






2 Functional Relationships(s)
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1 Treatment of OVCAR-3 cells with cisplatin, etoposide or epirubicin for two hours resulted in a marked augmentation of EGF-R expression and growth inhibition, on the other hand, incubation with substances blocking RNA or protein synthesis, actinomycin-D and cycloheximide, resulted in a reduction of both EGF-R expression and growth rate. Cisplatin epidermal growth factor receptor Homo sapiens
2 Treatment of OVCAR-3 cells with cisplatin, etoposide or epirubicin for two hours resulted in a marked augmentation of EGF-R expression and growth inhibition, on the other hand, incubation with substances blocking RNA or protein synthesis, actinomycin-D and cycloheximide, resulted in a reduction of both EGF-R expression and growth rate. Cisplatin epidermal growth factor receptor Homo sapiens