Title : Identification of 3'-methoxy-4'-nitroflavone as a pure aryl hydrocarbon (Ah) receptor antagonist and evidence for more than one form of the nuclear Ah receptor in MCF-7 human breast cancer cells.

Pub. Date : 1995 Jan 10

PMID : 7840652






2 Functional Relationships(s)
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1 In MCF-7 cells cotreated with flavones 1 or 2 (0.01 to 10 microM) plus TCDD or [3H]TCDD, there was a concentration-dependent inhibition of TCDD-induced CYP1A1 mRNA levels and formation of radiolabeled nuclear Ah receptor complex. Flavones cytochrome P450 family 1 subfamily A member 1 Homo sapiens
2 However, under these same conditions the flavones inhibited TCDD-induced CYP1A1 gene expression. Flavones cytochrome P450 family 1 subfamily A member 1 Homo sapiens