Title : Structure-activity relationship studies of CNS agents. Part 14: Structural requirements for the 5-HT1A and 5-HT2A receptor selectivity of simple 1-(2-pyrimidinyl)piperazine derivatives.

Pub. Date : 1994 Nov

PMID : 7838864






1 Functional Relationships(s)
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1 The topography of a molecule and the stereoelectronic effects of the thiophene rings are the major factors responsible for the high affinity and selectivity of 26 towards 5-HT2A sites. Thiophenes 5-hydroxytryptamine receptor 2A Homo sapiens