Title : Function of wild-type or mutant Rac2 and Rap1a GTPases in differentiated HL60 cell NADPH oxidase activation.

Pub. Date : 1995 Feb 1

PMID : 7833480






2 Functional Relationships(s)
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1 production by the differentiated cell line expressing GTPase-defective V12 Rap1a was also significantly inhibited, a finding that is consistent with a requirement for cycling between guanosine diphosphate- and GTP-bound forms of Rap1a for continuous NADPH oxidase activation in intact neutrophils. Guanosine Diphosphate RAP1A, member of RAS oncogene family Homo sapiens
2 production by the differentiated cell line expressing GTPase-defective V12 Rap1a was also significantly inhibited, a finding that is consistent with a requirement for cycling between guanosine diphosphate- and GTP-bound forms of Rap1a for continuous NADPH oxidase activation in intact neutrophils. Guanosine Diphosphate RAP1A, member of RAS oncogene family Homo sapiens