Pub. Date : 1994 Dec 30
PMID : 7806495
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thrombin is inhibited by the serpins antithrombin and heparin cofactor II (HCiI) in reactions that are accelerated markedly by specific glycosaminoglycans. | Glycosaminoglycans | coagulation factor II, thrombin | Homo sapiens |
| 2 | The present study examines the role of anion-binding exosite II of thrombin in the interaction with glycosaminoglycans and HCII. | Glycosaminoglycans | coagulation factor II, thrombin | Homo sapiens |
| 3 | Acceleration of thrombin inhibition by serpins in the presence of glycosaminoglycans is proposed to occur by a template mechanism, in which inhibitor and protease bind simultaneously to the same glycosaminoglycan chain, facilitating their interaction. | Glycosaminoglycans | coagulation factor II, thrombin | Homo sapiens |
| 4 | Acceleration of thrombin inhibition by serpins in the presence of glycosaminoglycans is proposed to occur by a template mechanism, in which inhibitor and protease bind simultaneously to the same glycosaminoglycan chain, facilitating their interaction. | Glycosaminoglycans | coagulation factor II, thrombin | Homo sapiens |
| 5 | Specific mutations in exosite II (R89E, R245E, K248E, and K252E) disrupted thrombin binding to both dermatan sulfate and heparin, indicating that both glycosaminoglycans bind to a common site in exosite II. | Glycosaminoglycans | coagulation factor II, thrombin | Homo sapiens |