Pub. Date : 1995 May 20
PMID : 7796923
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Elevated plasma ANP level, decreased atrial ANP concentration and increased ventricular ANP and BNP contents were observed in the DOCA-salt group when compared with the control group (p < 0.01). | Desoxycorticosterone Acetate | natriuretic peptide A | Rattus norvegicus |
| 2 | The ratio of BNP/ANP in the ventricle of the DOCA-salt rats was 50% of the control rats. | Desoxycorticosterone Acetate | natriuretic peptide A | Rattus norvegicus |
| 3 | The elevated plasma ANP secreted from the heart seems to reflect a defensive compensatory mechanism to counteract hypertension, and that ANP is the major natriuretic peptide secreted from the cardiac ventricle in DOCA-salt hypertensive rats. | Desoxycorticosterone Acetate | natriuretic peptide A | Rattus norvegicus |
| 4 | These results indicate that the down-regulation of NP-R, especially C-receptor, was induced in the lung and renal cortex when plasma ANP levels were elevated in DOCA-salt hypertensive rats. | Desoxycorticosterone Acetate | natriuretic peptide A | Rattus norvegicus |
| 5 | In conclusion, our results suggest that down-regulation of C-receptor in the lung and kidney contributes to maintaining higher plasma ANP levels and maybe responsible for the counter-regulatory role of endogenous ANP in DOCA-salt rats. | Desoxycorticosterone Acetate | natriuretic peptide A | Rattus norvegicus |