Title : A subtype of alpha 1 adrenoceptor mediates depression of conduction in Purkinje fibers exposed to halothane.

Pub. Date : 1995 Jun

PMID : 7793657






1 Functional Relationships(s)
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1 Another alpha 1 subtype (alpha 1A), sensitive to the competitive antagonist WB4101, increases spontaneous rate and action potential duration by a mechanism thought to involve hydrolysis of membrane phosphoinositides by phospholipase C. This study examined the dose-response relation and receptor-effector mechanisms underlying depression of conduction in canine Purkinje fibers by epinephrine with halothane. Halothane adrenoceptor alpha 1A Canis lupus familiaris