Title : Modulation of methylenedioxymethamphetamine-induced striatal dopamine release by the interaction between serotonin and gamma-aminobutyric acid in the substantia nigra.

Pub. Date : 1995 Jun

PMID : 7791076






2 Functional Relationships(s)
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1 Infusion of the 5-HT2A/2C antagonist ritanserin into the striatum or the ipsilateral substantia nigra also significantly attenuated MDMA-induced dopamine release in the striatum. Dopamine 5-hydroxytryptamine receptor 2A Rattus norvegicus
2 Furthermore, this increase in striatal dopamine efflux produced by MDMA is regulated, in part, by 5-HT2A/2C receptors in the striatum and the substantia nigra and ultimately by GABAergic input into the substantia nigra. Dopamine 5-hydroxytryptamine receptor 2A Rattus norvegicus