Title : Methamphetamine-induced nuclear c-Fos in rat brain regions.

Pub. Date : 1995 Jan

PMID : 7787765






3 Functional Relationships(s)
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1 Methamphetamine-induced nuclear c-Fos in rat brain regions. Methamphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 To explore the possible robust changes in neuronal activity in dopamine-poor brain regions after an indirect dopamine agonist, methamphetamine, we have investigated its effects on c-fos expression in rat brain using immunocytochemistry of c-Fos. Methamphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
3 Intraperitoneal injection of methamphetamine (1.6-4.8 mg/kg), but not of saline, induced a widespread nuclear c-Fos-like immunoreactivity in the pyriform cortex and olfactory tubercle with greatest density followed by the II-VI layers of the neocortex, amygdala, hypothalamus, thalamus, nucleus accumbens and striatum. Methamphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus