Pub. Date : 1995 Feb 17
PMID : 7777184
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differential effects of [3H]nemonapride and [3H]spiperone binding on human dopamine D4 receptors. | Spiperone | Rho GDP dissociation inhibitor beta | Homo sapiens |
| 2 | We compared some binding parameters of [3H]nemonapride and [3H]spiperone in human dopamine D4 (hD4) receptors with three different numbers of tandem repeat units. | Spiperone | Rho GDP dissociation inhibitor beta | Homo sapiens |
| 3 | Although both of the radioligands showed similar affinity constants for each hD4 receptor variant, the maximal number of binding sites labeled by [3H]nemonapride was approximately 1.35-fold higher than that by [3H]-spiperone for all variants. | Spiperone | Rho GDP dissociation inhibitor beta | Homo sapiens |
| 4 | Estimated Ki values for the inhibition of [3H]nemonapride binding by a series of dopaminergic ligands were highly correlated to respective values obtained for the inhibition of [3H]spiperone binding to each hD4 receptor. | Spiperone | Rho GDP dissociation inhibitor beta | Homo sapiens |