Protein Name Rho GDP dissociation inhibitor beta
Organism Homo sapiens
Gene ID 397
Gene Symbol


UniProt P52566 (GDIR2_HUMAN), A0A024RAS5 (A0A024RAS5_HUMAN)
Relationships Total Number of functionally related compound(s) : 100
Total Number of Articles : 94

Rho GDP dissociation inhibitor beta

Gene Summary

Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]

  • rho GDP-dissociation inhibitor 2
  • Rho GDI 2
  • Rho GDP dissociation inhibitor (GDI) beta
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