Pub. Date : 1995 May 30
PMID : 7766635
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | By screening a number of potential target sites for triple helix formation within mammalian genes that allow genetic selection in cell culture, we have identified a site within intron 1 of the hamster adenine phosphoribosyltransferase (APRT) gene that specifically binds a triplex-forming oligodeoxyribonucleotide (TFO) with high affinity. | tfo | adenine phosphoribosyltransferase | Homo sapiens |
| 2 | This high-affinity binding is very specific, as a 10(5)-fold excess of genomic DNA reduced triplex formation less than 10-fold, and within a 6928-bp plasmid bearing the APRT gene, only restriction fragments containing the intron 1 site were found to bind the TFO. | tfo | adenine phosphoribosyltransferase | Homo sapiens |