Title : SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1.

Pub. Date : 1995 May 8

PMID : 7750577






1 Functional Relationships(s)
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1 We now show that one of these compounds (SB 203580) inhibits RK in vitro (IC50 = 0.6 microM), suppresses the activation of MAPKAP kinase-2 and prevents the phosphorylation of heat shock protein (HSP) 27 in response to interleukin-1, cellular stresses and bacterial endotoxin in vivo. SB 203580 heat shock protein family B (small) member 1 Homo sapiens