Title : Isolation of a high affinity inhibitor of urokinase-type plasminogen activator by phage display of ecotin.

Pub. Date : 1995 May 19

PMID : 7744876






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Isolation of a high affinity inhibitor of urokinase-type plasminogen activator by phage display of ecotin. ecotin plasminogen activator, urokinase Homo sapiens
2 However, although the catalytic domain of human urokinase-type plasminogen activator (uPA) has 40% identity to bovine trypsin and the substrate specificities of these two proteases are virtually identical, ecotin inhibits uPA almost 10,000-fold less efficiently than trypsin. ecotin plasminogen activator, urokinase Homo sapiens
3 However, although the catalytic domain of human urokinase-type plasminogen activator (uPA) has 40% identity to bovine trypsin and the substrate specificities of these two proteases are virtually identical, ecotin inhibits uPA almost 10,000-fold less efficiently than trypsin. ecotin plasminogen activator, urokinase Homo sapiens