Protein Name plasminogen activator, urokinase
Organism Homo sapiens
Gene ID 5328
Gene Symbol

PLAU

UniProt P00749 (UROK_HUMAN), Q59GZ8 (Q59GZ8_HUMAN), B4DNJ4 (B4DNJ4_HUMAN), A0A024QZM9 (A0A024QZM9_HUMAN)
Relationships Total Number of functionally related compound(s) : 860
Total Number of Articles : 1233
Description

plasminogen activator, urokinase

Gene Summary

This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

synonyms
  • urokinase-type plasminogen activator
  • U-plasminogen activator
  • plasminogen activator, urinary
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Properties