Title : Selective serotonin reuptake inhibitors and theophylline metabolism in human liver microsomes: potent inhibition by fluvoxamine.

Pub. Date : 1995 Feb

PMID : 7742153

1 Functional Relationships(s)
Compound Name
Protein Name
1 Ethanol and fluvoxamine both inhibited 8-hydroxylation by about 45% and, in combination, the compounds decreased the formation of 1,3-dimethyluric acid by 90%, indicating that CYP1A2 and CYP2E1 are equally important isoforms for the 8-hydroxylation of theophylline. Fluvoxamine cytochrome P450 family 2 subfamily E member 1 Homo sapiens