Pub. Date : 1995 May
PMID : 7734315
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The induction of mdr1 RNA expression by three anthracyclines, (doxorubicin, daunorubicin, epirubicin), VP-16 and two vinca alkaloids (vincristine, vinblastine) was semiquantitatively assessed by scanning Northern blots on a phosphorimager. | Epirubicin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | A significant increase (P < 0.02) in expression of mdr1 was noted within 4 hrs of exposure to 1.5 micrograms ml-1 daunorubicin or epirubicin. | Epirubicin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | With increasing concentrations of daunorubicin or epirubicin in a fixed 24 h time period, mdr1 expression increased, although a biphasic response was seen. | Epirubicin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Based on MRK 16 binding, an increase in P-gp levels was seen in the CEM/A7R line after a 24 h exposure to 1 microgram ml-1 daunorubicin or epirubicin. | Epirubicin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | The rapid increase in mdr1 expression after a short period of exposure to doxorubicin, daunorubicin or epirubicin suggests that induction of mdr1 expression may have an important role in the development of drug-resistant tumours. | Epirubicin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | The rapid increase in mdr1 expression after a short period of exposure to doxorubicin, daunorubicin or epirubicin suggests that induction of mdr1 expression may have an important role in the development of drug-resistant tumours. | Epirubicin | ATP binding cassette subfamily B member 1 | Homo sapiens |