Pub. Date : 1995 Feb
PMID : 7723245
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | beta 2-microglobulin (beta 2m) induces an osteoclast-mediated net calcium efflux from neonatal mouse calvariae which occurs only after 48 hours of incubation, suggesting that beta 2m acts via other growth factors. | Calcium | beta-2 microglobulin | Mus musculus |
| 2 | beta 2-microglobulin (beta 2m) induces an osteoclast-mediated net calcium efflux from neonatal mouse calvariae which occurs only after 48 hours of incubation, suggesting that beta 2m acts via other growth factors. | Calcium | beta-2 microglobulin | Mus musculus |
| 3 | beta 2-microglobulin (beta 2m) induces an osteoclast-mediated net calcium efflux from neonatal mouse calvariae which occurs only after 48 hours of incubation, suggesting that beta 2m acts via other growth factors. | Calcium | beta-2 microglobulin | Mus musculus |
| 4 | However, the difference (delta) between the calcium efflux induced in calvariae incubated with and without beta 2m in basal medium and that in calvariae incubated with and without beta 2m in indomethacin supplemented medium was similar, suggesting a prostaglandin independent mechanism. | Calcium | beta-2 microglobulin | Mus musculus |
| 5 | In contrast, pre-incubating calvariae with either anti-IL-1 beta or IL-1 beta RA did not alter basal calcium efflux but completely blocked the beta 2m induced calcium efflux. | Calcium | beta-2 microglobulin | Mus musculus |
| 6 | Thus, the beta 2m-induced calcium efflux observed in neonatal mouse calvariae is dependent on interleukin-1 beta but not prostaglandins. | Calcium | beta-2 microglobulin | Mus musculus |