| Protein Name | beta-2 microglobulin |
|---|---|
| Organism | Mus musculus |
| Gene ID | 12010 |
| Gene Symbol | B2m |
| UniProt | P01887 (B2MG_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
112
Total Number of Articles : 120 |
Description |
beta-2 microglobulin |
| Gene Summary |
Predicted to enable several functions, including MHC class II protein complex binding activity; peptide antigen binding activity; and protein homodimerization activity. Involved in learning or memory; negative regulation of cell differentiation; and sensory perception of smell. Acts upstream of or within several processes, including antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; cellular response to iron(III) ion; and multicellular organismal-level iron ion homeostasis. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and retina. Used to study hemochromatosis. Human ortholog(s) of this gene implicated in arthritis; immunodeficiency 43; and inflammatory bowel disease. Orthologous to human B2M (beta-2-microglobulin). [provided by Alliance of Genome Resources, Jul 2025] |
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