Title : Site selective bis-intercalation of a homodimeric thiazole orange dye in DNA oligonucleotides.

Pub. Date : 1995 Mar 11

PMID : 7708489






5 Functional Relationships(s)
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Protein Name
Organism
1 TOTO binds strongly to all the oligonucleotides used, but usually more than one complex is observed and exchange between different binding sites broadens the lines in the NMR spectra. Oligonucleotides HOP homeobox Homo sapiens
2 Complete precipitation occurs when TOTO is bound to small oligonucleotides. Oligonucleotides HOP homeobox Homo sapiens
3 The 1:1 complex of TOTO with the oligonucleotide d(CCGACTGATGC):d (GCATCAGTCGG) gave only one complex that was shown to be a bis-intercalation in the CTGA:TCAG binding site. Oligonucleotides HOP homeobox Homo sapiens
4 The 1:1 complex of TOTO with the oligonucleotide d(CCGCTAGCG):d(CGCTAGCGG) containing a CTAG:CTAG binding site was similarly characterized by NMR. Oligonucleotides HOP homeobox Homo sapiens
5 It was concluded that the binding of TOTO to larger oligonucleotides is site selective with CTAG:CTAG as the preferred binding site. Oligonucleotides HOP homeobox Homo sapiens