Title : Synthesis of human osteocalcins: gamma-carboxyglutamic acid at position 17 is essential for a calcium-dependent conformational transition.

Pub. Date : 1994 Jul-Aug

PMID : 7696837






2 Functional Relationships(s)
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1 Circular dichroism measurement showed that the conformation of osteocalcin containing three Gla residues dramatically changed on addition of calcium ions, whereas the peptide containing glutamic acid at position 17 did not. Calcium bone gamma-carboxyglutamate protein Homo sapiens
2 These findings clearly show that the Gla residue at position 17 is essential for a calcium-dependent conformational transition of osteocalcin. Calcium bone gamma-carboxyglutamate protein Homo sapiens