Pub. Date : 1993 Aug 10
PMID : 7691626
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anxiolytic effects of the 5-HT1A receptor agonist ipsapirone in the rat: neurobiological correlates. | ipsapirone | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |
| 2 | Ipsapirone, a 5-HT1A receptor agonist, is a psychoactive compound with anxiolytic and antidepressive properties. | ipsapirone | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |
| 3 | It is concluded that ipsapirone exhibits its anxiolytic effects, at least partially, by stimulating presynaptic somatodendritic 5-HT1A receptors in the brain stem raphe nuclei (i.e., the dorsal raphe), resulting in attenuation of presynaptic cell firing and subsequent inhibition of serotonergic neurotransmission in the limbic system (i.e., the hippocampus). | ipsapirone | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |