Pub. Date : 1993 May
PMID : 7688545
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bradykinin inhibits cyclic AMP accumulation in D384-human astrocytoma cells via a calcium-dependent inhibition of adenylyl cyclase. | Cyclic AMP | kininogen 1 | Homo sapiens |
| 2 | Bradykinin causes a concentration-dependent, transient rise in intracellular Ca2+ and a sustained inhibition of forskolin-, dopamine- and 5"-N-ethyl-carboxamidoadenosine (NECA)-stimulated cAMP accumulation in D384 astrocytoma cells. | Cyclic AMP | kininogen 1 | Homo sapiens |
| 3 | Chelation of intracellular calcium abolished bradykinin"s inhibitory effect on cAMP accumulation. | Cyclic AMP | kininogen 1 | Homo sapiens |
| 4 | Bradykinin treatment, which attenuates cAMP accumulation in intact cells, did not do so in plasma membranes. | Cyclic AMP | kininogen 1 | Homo sapiens |
| 5 | These findings suggest that bradykinin-induced inhibition of cAMP formation in D384 cells requires mobilization of [Ca2+]i and subsequent entry of Ca2+ which directly interacts with a component of the adenylyl cyclase system. | Cyclic AMP | kininogen 1 | Homo sapiens |