Title : Thrombin- and cathepsin G-induced platelet aggregation: effect of protein kinase C inhibitors.

Pub. Date : 1993 Apr

PMID : 7683848






1 Functional Relationships(s)
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1 Protein kinase C (PKC) is a signal-transducing enzyme that is an important regulator of postreceptor intracellular changes following exposure of platelets to thrombin and cathepsin G. Inhibitors of purified PKC, e.g., staurosporine and calphostin C, have been frequently used to elucidate biochemical mechanisms mediated by the intracellular PKC following platelet activation by proteases. Carbon coagulation factor II, thrombin Homo sapiens