Title : Effect of macromolecules on the structure of the mitochondrial inter-membrane space and the regulation of hexokinase.

Pub. Date : 1993 May 6

PMID : 7683206






2 Functional Relationships(s)
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1 The results suggest three things: (i) that contact sites are probably more frequent in the intact cell than in vitro in the absence of macromolecules, (ii) that the contact preference of hexokinase serves rather the ADP supply of the translocator than the ATP transfer to the enzyme and (iii) that the total cellular hexokinase activity may be regulated by specific binding of the enzyme to the contact sites, either because of a different pore structure or because of additional components exclusively exposed in these sites. Adenosine Diphosphate hexokinase 1 Homo sapiens
2 The results suggest three things: (i) that contact sites are probably more frequent in the intact cell than in vitro in the absence of macromolecules, (ii) that the contact preference of hexokinase serves rather the ADP supply of the translocator than the ATP transfer to the enzyme and (iii) that the total cellular hexokinase activity may be regulated by specific binding of the enzyme to the contact sites, either because of a different pore structure or because of additional components exclusively exposed in these sites. Adenosine Diphosphate hexokinase 1 Homo sapiens