Title : Inactivation of glutathione peroxidase by nitric oxide. Implication for cytotoxicity.

Pub. Date : 1995 Sep 8

PMID : 7673130






2 Functional Relationships(s)
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1 The IC50 of SNAP for GPx was 2 microM at 1 h of incubation and was 20% of the IC50 for another thiol enzyme, glyceraldehyde-3-phosphate dehydrogenase, in which a specific cysteine residue is known to be nitrosylated. Cysteine glyceraldehyde-3-phosphate dehydrogenase Homo sapiens
2 The similarity of the inactivation with SNAP and reactivation with dithiothreitol of GPx to that of glyceraldehyde-3-phosphate dehydrogenase, suggested that NO released from SNAP modified a cysteine-like essential residue on GPx. Cysteine glyceraldehyde-3-phosphate dehydrogenase Homo sapiens