Title : Replacements of leucine 87 in human insulin receptor alter affinity for insulin.

Pub. Date : 1995 Sep 15

PMID : 7665623






5 Functional Relationships(s)
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1 Replacements of leucine 87 in human insulin receptor alter affinity for insulin. Leucine insulin receptor Homo sapiens
2 In a previous analysis, we identified a point mutation that substituted Pro (CCG) for Leu (CTG) at amino acid 87 in the alpha-subunit of the insulin receptor (IR) in a Japanese patient with leprechaunism. Leucine insulin receptor Homo sapiens
3 In a previous analysis, we identified a point mutation that substituted Pro (CCG) for Leu (CTG) at amino acid 87 in the alpha-subunit of the insulin receptor (IR) in a Japanese patient with leprechaunism. Leucine insulin receptor Homo sapiens
4 The Pro-87 IR reduced the insulin binding affinity to about 15% of Leu-87 IR, and the dissociation of insulin in Pro-87 IR was more rapid than in Leu-87 IR. Leucine insulin receptor Homo sapiens
5 The Pro-87 IR reduced the insulin binding affinity to about 15% of Leu-87 IR, and the dissociation of insulin in Pro-87 IR was more rapid than in Leu-87 IR. Leucine insulin receptor Homo sapiens