Title : Differential mutagenicity and cytotoxicity of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol and (+/-)-anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide in genetically engineered human fibroblasts.

Pub. Date : 1995 Feb

PMID : 7662121






1 Functional Relationships(s)
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1 The XPA cells were more susceptible than the normal cells to the cytotoxic effects of both CYP1A1-metabolized BPD and exogenously supplied (+/-)-anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10- epoxide (BPDE). 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide XPA, DNA damage recognition and repair factor Homo sapiens