Protein Name XPA, DNA damage recognition and repair factor
Organism Homo sapiens
Gene ID 7507
Gene Symbol


UniProt P23025 (XPA_HUMAN)
Relationships Total Number of functionally related compound(s) : 205
Total Number of Articles : 235

XPA, DNA damage recognition and repair factor

Gene Summary

This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017]

  • DNA repair protein complementing XP-A cells
  • xeroderma pigmentosum group A-complementing protein
  • xeroderma pigmentosum, complementation group A
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