| Protein Name | XPA, DNA damage recognition and repair factor |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 7507 |
| Gene Symbol | XPA |
| UniProt | P23025 (XPA_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
205
Total Number of Articles : 235 |
Description |
XPA, DNA damage recognition and repair factor |
| Gene Summary |
This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017] |
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