Title : Rapid and persistent desensitization of m3 muscarinic acetylcholine receptor-stimulated phospholipase D. Concomitant sensitization of phospholipase C.

Pub. Date : 1995 Aug 25

PMID : 7650010






3 Functional Relationships(s)
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1 Furthermore, PLD stimulation by directly activated protein kinase C and GTP-binding proteins was unaltered in carbachol-pretreated cells. Guanosine Triphosphate glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
2 The rapid and long lasting desensitization of the PLD response is apparently not due to a loss of cell surface receptors or PLD activation by GTP-binding proteins, but it may involve, at least initially, an uncoupling of receptors from GTP-binding proteins and most likely a loss of an as yet undefined essential transducing component. Guanosine Triphosphate glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
3 The rapid and long lasting desensitization of the PLD response is apparently not due to a loss of cell surface receptors or PLD activation by GTP-binding proteins, but it may involve, at least initially, an uncoupling of receptors from GTP-binding proteins and most likely a loss of an as yet undefined essential transducing component. Guanosine Triphosphate glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens