Title : Effects of glucose and SNK-860, an aldose reductase inhibitor, on the polyol pathway and chemiluminescence response of human neutrophils in vitro.

Pub. Date : 1995 May

PMID : 7648800






1 Functional Relationships(s)
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1 These results suggest that impaired respiratory burst induced by high-glucose concentrations is caused by competition for NADPH resulting from increased polyol pathway activity and/or glycation and that an AR inhibitor may be capable in part of preventing increased susceptibility to infection in diabetic patients. Glucose aldo-keto reductase family 1 member B Homo sapiens