Title : DL-beta,beta-difluoroglutamic acid mediates position-dependent enhancement or termination of pteroylpoly(gamma-glutamate) synthesis catalyzed by folylpolyglutamate synthetase.

Pub. Date : 1995 Aug 20

PMID : 7646057






1 Functional Relationships(s)
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1 Analysis of the products synthesized by purified FPGS, however, suggests that while addition of the first gamma-Glu to beta,beta-F2MTX is highly efficient, subsequent additions occur at a negligible rate; this premise was confirmed by directly comparing the in vitro FPGS substrate activity of MTX-gamma-Glu and beta,beta-F2MTX-gamma-Glu. gamma-glu folylpolyglutamate synthase Homo sapiens