Title : Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin.

Pub. Date : 1995 Aug

PMID : 7634398






3 Functional Relationships(s)
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1 Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin. Curcumin epidermal growth factor receptor Homo sapiens
2 There was no effect of curcumin treatment on the amount of surface expression of labeled EGF-R and inhibition of EGF-mediated tyrosine phosphorylation of EGF-R by curcumin was mediated by a reversible mechanism. Curcumin epidermal growth factor receptor Homo sapiens
3 These findings demonstrate that curcumin is a potent inhibitor of a growth stimulatory pathway, the ligand-induced activation of EGF-R, and may potentially be useful in developing anti-proliferative strategies to control tumor cell growth. Curcumin epidermal growth factor receptor Homo sapiens