Pub. Date : 1995 Jul 1
PMID : 7619077
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In recombinant rat liver PFK-2/FBPase-2, mutation of Arg-225 to Ser increased the Km of PFK-2 for fructose-6-phosphate (Fru-6-P) 7-fold at pH 6 and decreased PFK-2 activity at suboptimal substrate concentrations between pH 6 and 9.5. | fructose-6-phosphate | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | Rattus norvegicus |
| 2 | In recombinant rat liver PFK-2/FBPase-2, mutation of Arg-225 to Ser increased the Km of PFK-2 for fructose-6-phosphate (Fru-6-P) 7-fold at pH 6 and decreased PFK-2 activity at suboptimal substrate concentrations between pH 6 and 9.5. | fructose-6-phosphate | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | Rattus norvegicus |
| 3 | In recombinant rat liver PFK-2/FBPase-2, mutation of Arg-225 to Ser increased the Km of PFK-2 for fructose-6-phosphate (Fru-6-P) 7-fold at pH 6 and decreased PFK-2 activity at suboptimal substrate concentrations between pH 6 and 9.5. | fructose-6-phosphate | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | Rattus norvegicus |
| 4 | In recombinant rat liver PFK-2/FBPase-2, mutation of Arg-225 to Ser increased the Km of PFK-2 for fructose-6-phosphate (Fru-6-P) 7-fold at pH 6 and decreased PFK-2 activity at suboptimal substrate concentrations between pH 6 and 9.5. | fructose-6-phosphate | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | Rattus norvegicus |
| 5 | In recombinant rat liver PFK-2/FBPase-2, mutation of Arg-225 to Ser increased the Km of PFK-2 for fructose-6-phosphate (Fru-6-P) 7-fold at pH 6 and decreased PFK-2 activity at suboptimal substrate concentrations between pH 6 and 9.5. | fructose-6-phosphate | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | Rattus norvegicus |
| 6 | In recombinant rat liver PFK-2/FBPase-2, mutation of Arg-225 to Ser increased the Km of PFK-2 for fructose-6-phosphate (Fru-6-P) 7-fold at pH 6 and decreased PFK-2 activity at suboptimal substrate concentrations between pH 6 and 9.5. | fructose-6-phosphate | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | Rattus norvegicus |
| 7 | In recombinant rat muscle PFK-2/FBPase-2, mutation of Arg-104 to Ser increased the Km for Fru-6-P 60-fold, increased the IC50 of citrate, increased the Vmax. | fructose-6-phosphate | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | Rattus norvegicus |
| 8 | The findings indicate that Arg-104 is involved in Fru-6-P binding in the PFK-2 domain and that it might also bind citrate. | fructose-6-phosphate | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | Rattus norvegicus |