Title : The SNF2/SWI2/GAM1/TYE3/RIC1 gene is involved in the coordinate regulation of phospholipid synthesis in Saccharomyces cerevisiae.

Pub. Date : 1995 Feb

PMID : 7608126






3 Functional Relationships(s)
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1 Genes involved in the phospholipid synthesis of Saccharomyces cerevisiae, such as PEM1, PEM2, PSS, and INO1, are coordinately repressed by myo-inositol and choline. Inositol inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C
2 Analysis using various lacZ fusion constructs containing promoters for genes in phospholipid synthesis revealed that the expression of myo-inositol-choline-regulated genes, PEM1, PEM2, PSS, CKI, and INO1, was markedly decreased in the snf2/swi2/gam1/tye3/ric1 background, but the expression of a constitutive gene, PIS, was not. Inositol inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C
3 We conclude that SNF2/SWI2/GAM1/TYE3/RIC1 is a positive regulatory gene required for the expression of not only INO1 gene, but also of myo-inositol-choline-regulated genes in general. Inositol inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C