Pub. Date : 1995 Apr
PMID : 7599928
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differential effects of phosphoramidon on contractile responses to angiotensin II in rat blood vessels. | phosphoramidon | angiotensinogen | Rattus norvegicus |
| 2 | Phosphoramidon blocked the responses to AII in a concentration-dependent manner, whereas even very high concentrations of phosphoramidon (100 microM) failed to affect the tension responses evoked by ET-1 and AVP in all three preparations. | phosphoramidon | angiotensinogen | Rattus norvegicus |
| 3 | Low concentrations of phosphoramidon (10 microM) produced significant increases in EC50 values for AII in tail artery (P < 0.01) and mesenteric artery (P < 0.05) but not in aorta. | phosphoramidon | angiotensinogen | Rattus norvegicus |
| 4 | Phosphoramidon-evoked rightward shifts in the C-R curves to AII were much higher than those to big ET-1 in both mesenteric artery and tail artery. | phosphoramidon | angiotensinogen | Rattus norvegicus |
| 5 | It is concluded that the vasoconstrictor responses to AII in mesenteric artery and tail artery may be mediated by the release of endothelins from the endothelium by increased formation from big ET, an effect that is blocked by phosphoramidon. | phosphoramidon | angiotensinogen | Rattus norvegicus |