Title : Modelling the effects of age-related mtDNA mutation accumulation; complex I deficiency, superoxide and cell death.

Pub. Date : 1995 May 24

PMID : 7599205






1 Functional Relationships(s)
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1 Since the likeliest target of mitochondrial mutation is Complex I, deficiency of which causes MnSOD-inhibitable lethality, we propose that rising mtDNA mutations with age will cause an increase in superoxide-mediated cell death. Superoxides superoxide dismutase 2, mitochondrial Mus musculus