Title : Allosteric regulation of [3H]vinblastine binding to P-glycoprotein of MCF-7 ADR cells by dexniguldipine.

Pub. Date : 1995 Jun 16

PMID : 7598747






1 Functional Relationships(s)
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1 These results suggest that P-glycoprotein of MCF-7 ADR cell membranes possesses at least two drug acceptor sites which are allosterically coupled: receptor site-1 which binds vinca alkaloids, and receptor site-2 which binds 1,4-dihydropyridines such as dexniguldipine-HCl, which had the highest affinity of the tested derivatives. Vinca Alkaloids ATP binding cassette subfamily B member 1 Homo sapiens