Title : Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: evidence for the involvement of nuclear factor kappa B in the signaling mechanism.

Pub. Date : 1995 Nov

PMID : 7588208






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Inhibitors of NFkappaB, diethyldithiocarbamate, pyrrolidine dithiocarbamate, and N-acetyl cysteine prevent IL-1-induced iNOS expression at the level of messenger RNA, protein, and nitrite generation. pyrrolidine dithiocarbamic acid nitric oxide synthase 2 Rattus norvegicus
2 IL-1-induced translocation of NF kappa B was blocked by 100 microns 100 microM diethyldithiocarbamate or 100 microM pyrrolidine dithiocarbamate, further establishing a critical role for NF kappa B in the induction of iNOS by IL-1 in rat pancreatic beta-cells. pyrrolidine dithiocarbamic acid nitric oxide synthase 2 Rattus norvegicus