Title : Expression of multidrug resistance-associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution.

Pub. Date : 1995 Nov 15

PMID : 7585598






3 Functional Relationships(s)
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1 MRP transfectants displayed increased resistance to several lipophilic drugs, including doxorubicin, daunorubicin, etoposide, actinomycin D, vincristine, and vinblastine. Daunorubicin ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus
2 Analysis of drug kinetics using radiolabeled daunorubicin revealed decreased accumulation and increased efflux in MRP transfectants. Daunorubicin ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus
3 Confocal microscopic analysis of intracellular daunorubicin in MRP transfectants was consistent with reduced intracellular drug concentrations, and also revealed an altered pattern of intracellular drug distribution characterized by the initial accumulation of drug in a perinuclear location, followed by the development of a punctate pattern of drug scattered throughout the cytoplasm. Daunorubicin ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus