Title : Mechanistic kinship between hydroxylation and desaturation reactions: acyl-carbon bond cleavage promoted by pig and human CYP17 (P-450(17)alpha; 17 alpha-hydroxylase-17,20-lyase).

Pub. Date : 1995 Oct 31

PMID : 7578007






1 Functional Relationships(s)
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1 The aldehyde underwent cleavage to produce the 5,16-diene plus the 17 alpha-hydroxyandrogen, at rates approximately 8- and 3-fold higher than any physiological reaction catalyzed, in the absence of cytochrome b5, by the pig and human CYP17 isoforms, respectively. 17 alpha-hydroxyandrogen cytochrome P450 family 17 subfamily A member 1 Homo sapiens