Title : Effects of metalloproteinase inhibitors on leukotriene A4 hydrolase in human airway epithelial cells.

Pub. Date : 1995 Sep 28

PMID : 7575672






2 Functional Relationships(s)
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1 Of the metalloproteinase inhibitors examined, only captopril, bestatin, and fosinoprilat had appreciable inhibitory activity for LTA4 hydrolase in disrupted epithelial cells. fosinoprilat leukotriene A4 hydrolase Homo sapiens
2 Concentration-inhibition curves to captopril, bestatin, and fosinoprilat revealed IC50 values of 430 microM, 7 microM, and 1 mM, respectively, for disrupted-cell LTA4 hydrolase activity. fosinoprilat leukotriene A4 hydrolase Homo sapiens