Title : Urokinase-type plasminogen activator and its inhibitor PAI-1: predictors of poor response to tamoxifen therapy in recurrent breast cancer.

Pub. Date : 1995 May 17

PMID : 7563153






2 Functional Relationships(s)
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1 When patients were stratified by ER/PgR status, the only statistically significant association between uPA levels and reduced tamoxifen response was seen in the subset whose tumors possessed intermediate levels of ER/PgR (16% response in uPA-positive versus 60% response in uPA-negative tumors; OR = 0.13; 95% CI = 0.04-0.41). Tamoxifen progesterone receptor Homo sapiens
2 The association of PAI-1 expression and the response to tamoxifen was less pronounced when patients were stratified by ER/PgR status. Tamoxifen progesterone receptor Homo sapiens