Title : Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Pub. Date : 1995 Oct

PMID : 7560060






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We have previously shown that absence of the mouse mdr1a (also called mdr3) P-glycoprotein in mdr1a (-/-) "knockout" mice has a profound effect on the tissue distribution and elimination of vinblastine and ivermectin, and hence on the toxicity of these compounds. Vinblastine ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus
2 We have previously shown that absence of the mouse mdr1a (also called mdr3) P-glycoprotein in mdr1a (-/-) "knockout" mice has a profound effect on the tissue distribution and elimination of vinblastine and ivermectin, and hence on the toxicity of these compounds. Vinblastine ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus
3 We have previously shown that absence of the mouse mdr1a (also called mdr3) P-glycoprotein in mdr1a (-/-) "knockout" mice has a profound effect on the tissue distribution and elimination of vinblastine and ivermectin, and hence on the toxicity of these compounds. Vinblastine ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus