Title : Reduction of carrageenin oedema and the associated c-Fos expression in the rat lumbar spinal cord by nitric oxide synthase inhibitor.

Pub. Date : 1995 Jan

PMID : 7536097






3 Functional Relationships(s)
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1 We have studied the effect of systemic administration of a nitric oxide synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME) on carrageenin evoked c-Fos expression and thus the contribution of nitric oxide to this expression. NG-Nitroarginine Methyl Ester Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 We have studied the effect of systemic administration of a nitric oxide synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME) on carrageenin evoked c-Fos expression and thus the contribution of nitric oxide to this expression. NG-Nitroarginine Methyl Ester Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
3 ), the inactive isomer of L-NAME, produced a weak reduction of the number of superficial laminae Fos-LI neurones (26 +/- 8% reduction, P<0.05), without influencing the deep Fos-LI neurones (5 +/- 8% enhancement) or the oedema.8. NG-Nitroarginine Methyl Ester Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus