Title : Differential regulation of L-arginine transport and inducible NOS in cultured vascular smooth muscle cells.

Pub. Date : 1995 Mar

PMID : 7535004






4 Functional Relationships(s)
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1 Treatment of vascular SMC with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) resulted in parallel increases in L-arginine transport and nitric oxide (NO) synthesis, as measured by nitrite production. Nitrites tumor necrosis factor Rattus norvegicus
2 Treatment of vascular SMC with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) resulted in parallel increases in L-arginine transport and nitric oxide (NO) synthesis, as measured by nitrite production. Nitrites tumor necrosis factor Rattus norvegicus
3 Increasing the concentration of IL-1 beta and TNF-alpha caused a progressive elevation in nitrite production but did not further stimulate L-arginine uptake. Nitrites tumor necrosis factor Rattus norvegicus
4 Treatment of SMC with the combination of TNF-alpha and interferon-gamma (IFN-gamma) synergistically enhanced nitrite release without having any additional effect on L-arginine transport. Nitrites tumor necrosis factor Rattus norvegicus